Pulse Radiolysis Laboratory
pulselab@orange.ichtj.waw.pl  
Head: Prof. Krzysztof Bobrowski 
Links About Members Lectures/posters Publications Grants/Awards Instruments

Publications Page

2002
Ch. Schöneich, D. Pogocki, G. L. Hug, K. Bobrowski "Free radical reactions of methionine in peptides: mechanism relevant to a-amyloid oxidation and Alzheimer’s disease” J. Am. Chem. Soc. Submitted

Pawel B. Wisniowski, Ian Carmichael, Richard W. Fessenden, and Gordon L. Hug "Evidence for b-Scission in the Oxidation of Amino Acids", J. Phys. Chem. A. (2002), 106, 4573-4580

D. Pogocki, Ch. Schöneich, “Redox properties of Met35 in neurotoxic b-Amyloid peptide. A molecular modeling study” Chem. Res. Toxicol., 15, 408-418 (2002).

D. Pogocki, Ch. Schöneich, “Computational characterization of sulfur-oxygen bonded sulfuranyl radicals derived from alkyl- and (carboxyalkyl)thiopropionic acids: evidence for s*-type radicals” J. Org. Chem., 67, 1526-1535 (2002).

J.Grodkowski, P. Neta, E. Fujita, A. Mahammed, L. Simkovich, and Z. Gross "Reduction of Cobalt and Iron Corroles and Catalyzed Reduction of CO2" J. Phys. Chem. A (2002),106, 4772-4778

J. Grodkowski and P. Neta "Reaction Kinetics in the Ionic Liquid Methyltributylammonium Bis(Trifluoromethylsulfonyl)imide. Pulse Radiolysis Study of •CF3 Radical reactions” J. Phys. Chem. A (2002), 106, 5468-5473

A. Korzeniowska-Sobczuk, G. L. Hug, I. Carmichael, K. Bobrowski "Spectral, kinetics, and theoretical studies of radical cations derived from thioanisole and its carboxylic derivative” J. Phys. Chem. 2002, 106, 0000
Under construction!!!
2001
N. Varmenot, S. Remita, Z. Abedinzadeh, P. Wiœniowski, G. Strzelczak, K. Bobrowski "Oxidation processes of N,S-diacetyl-L-cysteine ethylester: influence of S-acetylation" J. Phys. Chem. A. (2001), 105, 6867;

D. Pogocki, Ch. Schöneich “Thiyl radicals abstract hydrogen atoms from carbohydrates: Reactivity and selectivity”, Free Radical Biol. Med., 31, 98-107 (2001).

D. Pogocki, E. Ghezzo-Schöneich, Ch. Schöneich J. “Conformational flexibility controls proton transfer between the methionine hydroxy sulfuranyl radical and the N-terminal amino group in Thr-(X)n-Met peptides” Phys. Chem. B.; 105, 1250-1259, (2001).

I. Spasojeviæ, I. Batiniæ-Haberle, R. D. Stevens, P. Hambright, A. N. Thorpe, J. Grodkowski, P. Neta,and I. Fridovich "Manganese(III) Biliverdin IX Dimethyl Ester: A Powerful Catalytic Scavenger of Superoxide Employing the Mn(III)/Mn(IV) Redox Couple" Inorg. Chem. (2001) 40, 726-739

J. Grodkowski and P. Neta "Copper-Catalyzed Radiolytic Reduction of CO2 to CO in Aqueous Solutions" J. Phys. Chem. B (2001), 105, 4967-4972

C. Schöneich, B. Miller, G. L. Hug, K. Bobrowski, B. Marciniak "Intermolecular complexes between sulfide radical cations from b-hydroxy sulfides and phosphate” Res. Chem. Interm. 2001, 27, 165.
Under construction!!!
2000
Christian Schöneich, Dariusz Pogocki, Pawe³ B. Wiœniowski, Gordon L. Hug and Krzysztof Bobrowski, "Intramolecular Sulfur-Oxygen Bond Formation in Radical Cations of N-acetylmethionine Amide", J. Am. Chem. Soc., 122, p.10224-10225 (2000).

D. Pogocki, P. Wiœniowski, G. L. Hug, K. Bobrowski. “Intramolecular sulfur-oxygen bond formation in radical cations of N-acetylmethionine amide. Ch. Schöneich” J. Am. Chem. Soc., 122, 10224-10225, (2000).

D. Pogocki, J. Sad³o “Hydroxyl Radical Induced Oxidation of Thiaproline Derivatives. An ESR Study” Nukleonika, 45, 101-108 (2000).

D. Pogocki, Ch.Schöneich. “Chemical Stability of Nucleic Acid Derived Drugs” J. Pharm. Sci. 89, 443-456, (2000).

J. Grodkowski and P. Neta "Cobalt Corrin Catalyzed Photoreduction of CO2" J. Phys. Chem. A (2000), 104, 1848-1853

J. Grodkowski and P. Neta "Ferrous Ions as Catalysts for Photochemical Reduction of CO2 in Homogeneous Solutions" J. Phys. Chem. A (2000) 104, 4475-4479

J. Grodkowski, T. Dhanasekaran, P. Neta, P. Hambright, B. S. Brunschwig, K. Shinozaki, and E. Fujita "Reduction of Cobalt and Iron Phthalocyanines and the Role of the Reduced Species in Catalyzed Photoreduction of CO2" J. Phys. Chem. A (2000) 104, 11332-11339

B. Beaver, V. Sharief, Y. Teng, R. DeMunshi, J. P. Guo, E. Katondo, D. Gallaher, D. Bunk, J. Grodkowski, and P. Neta "Development of Oxygen Scavenger Additives for Future Jet Fuels. A Role for Electron-Transfer-Initiated Oxygenation (ETIO) of 1,2,5-Trimethylpyrrole?" Energy&Fuels (2000) 14, 441-447

G. L. Hug, K. Bobrowski, H. Kozubek, B. Marciniak "Photooxidation of methionine-containing peptides by the 4-carboxybenzophenone triplet state in aqueous solution. Competition between intramolecular two-centered three-electron bonded (S.·.S)+ and (S.·.N)+ formation” Photochem. Photobiol. 2000, 72, 1.

G. L. Hug, K. Bobrowski, H. Kozubek, B. Marciniak, "pH Effects on the photooxidation of methionine derivatives by the 4-carboxybenzophenone triplet state” Nukleonika 2000, 45, 63.

G. Strzelczak, K. Bobrowski, H. Kozubek, J. Michalik, "ESR Study of radiation induced radicals in polycrystalline oligopeptides containing methionine” Nukleonika 2000, 45, 93.
Under construction!!!
1999
K.Bobrowski, G.L.Hug, B.Marciniak, C.Schöneich, P. B. Wiœniowski "Intramolecular Hydrogen Transfer During Oxidation of b-Hydroxysulfides and a-(Methyl)thioacetamide. Pulse Radiolysis and Flash Photolysis Studies" Res. Chem. Intermed., vol. 25, No. 3, pp. 285-297 (1999).

T. Dhanasekaran, J. Grodkowski, P. Neta, P. Hambright and Etsuko Fujita "p-Terphenyl-Sensitized Photoreduction of CO2 with Cobalt and Iron Porphyrins. Interaction between CO and Reduced Metalloporphyrins" J. Phys. Chem. A (1999) 103, 7742-7748

J. Mirkowski, J.Grodkowski, “Measurement System for Pulse Radiolysis at the Linear Electron Accelerator LAE 13/9” Nukleonika vol. 44 No.1 p. 71-78, 1999

K. Bobrowski, "Zastosowanie radiolizy impulsowej w badaniach reakcji foto-chemicznych" w „Metody badania mechanizmów reakcji fotochemicznych” Wydawnictwa Naukowe UAM, Poznañ, 1999, 139.

K. Bobrowski, J. Holcman, J. Poznañski, K. L. Wierzchowski, "Pulse radiolysis studies of intramolecular electron transfer in model peptides and proteins. 8. TrpNH+• ->TyrO• radical transformation in H-Trp-(Pro)n-Tyr-OH series of peptides" J. Phys. Chem. B. 1999, 103, 10316.

K. Bobrowski, "Electron migration in peptides and proteins" in Properties and reactions of radiation induced transients - selected topics, J. Mayer (ed.) 1999 PWN, Warszawa, pp.177-204.

Under construction!!!
1998
K. Bobrowski, D. Pogocki, Ch. Schöneich, “Oxidation of (carboxyl)thiopropionic acid derivatives by hydroxyl radicals. Mechanism nad kinetics of competitive inter- and intramolecular formation of s- and s*-type sulfuranyl radicals” J. Phys. Chem. A.; 102(51); 10512-10521 (1998).

P.Wiœniowski, K.Bobrowski "Hydroxyl Radical Induced Oxidation of a-(Methylthio)Acetamide in Aqueous Solutions" Annual Report INCT 1998, pp. 20-21

G. L. Hug, K. Bobrowski, H. Kozubek, B. Marciniak, "Photooxidation of methionine derivatives by the 4-carboxybenzophenone triplet state in aqueous solution. Intra-complex proton transfer involving the amino group” Photochem. Photobiol. 1998, 68, 785.

J. Mirkowski, J.Grodkowski, “Oprogramowanie do obs³ugi stanowiska pomiarowego radiolizy impulsowej. Program Radio96” Annual Report INCT 1998

J. Mirkowski, “Program do analizy zdjêæ elektroforezy – DNAnalyser” Annual Report INCT 1998

G. Strzelczak-Burliñska, K. Bobrowski, J. Holcman "Reduction of selected oligopeptides containing methionine induced by hydrated electrons" Radiat. Res. 1998, 150, 688.

K. Bobrowski, J. Holcman, J. Poznañski, K. L. Wierzchowski "Long range electron transfer between proline-bridged aromatic amino acids" w Photochemistry and Radiation Chemistry: Complementary Methods for the Study of Electron Transfer; Advances in Chemistry Series No. 254; Wishart J. F. and Nocera D. G. 1998, pp. 131-143.
Under construction!!!
Some Recent
G. Strzelczak-Burliñska, K. Bobrowski, D. Pogocki, J. Michalik "ESR study of radiation induced radicals in polycrystalline methionine and its homopeptides" Nukleonika 1997, 42, 333.

J. Grodkowski, D. Behar, P. Neta, and P. Hambright, "Iron Porphyrin-Catalyzed Reduction of CO2. Photochemical and Radiation Chemical Studies" J. Phys. Chem. A,1997, 101(3, 248-254

S. Cromer, P. Hambright, J. Grodkowski and P.Neta, "Tetrabenzoporhyrins: metal incorporation and exchange kinetics, ligational equilibria and pulse radiolysis studies" Porphyrins and Phtalocyanines 1997

K. Bobrowski, J. Holcman, J. Poznanski, K. L. Wierzchowski, "Pulse radiolysis studies of intramolecular electron transfer in model peptides and proteins. 7. Trp . -> TyrO. radical transformation in hen egg-white lysozyme. Effects of pH, temperature, Trp-62 oxidation and inhibitor binding" Biophys. Chem. 1997.

K. Bobrowski, "Zastosowanie radiolizy impulsowej w badaniach reakcji fotochemicznych" W: Metody badania mechanizmów reakcji fotochemicznych. Wydawnictwa Naukowe UAM, Poznañ 1997.

K. Bobrowski, J. Holcman, J. Poznanski, K. L. Wierzchowski, "Long range electron transfer between proline-bridged aromatic amino acids" In: Advances in Chemistry Series, 1997.

K. Bobrowski, "Electron migration in peptides and proteins" In: Properties and reactions of radiation induced transients - selected topics, J. Mayer (ed.) 1997 PWN, Warszawa.

K. Bobrowski, G. L. Hug, B. Marciniak, B. Miller, Ch. Schöneich, "Mechanism of one-electron oxidation of b-, g- and d-hydroxyalkyl sulfides. Catalysis through intramolecular proton transfer and sulfur-oxygen bond formation" J. Am. Chem. Soc.

K. Bobrowski, G. L. Hug, B. Marciniak, "Photooxidation of methionine derivatives by the 4-carboxybenzophenone triplet state in aqueous solution. Stabilization of sulfur-radical-cation centers". J. Phys. Chem..

P.Wiœniowski, K.Bobrowski "Reactions of Hydroxyl Radical with Thioamides" Annual Report INCT 1997, pp. 19-21.

Gordon L. Hug, Bronislaw Marciniak and Krzysztof Bobrowski "Acid-Base Equilibria Involved in Secondary Reactions Following the 4-Carboxybenzophenone Sensitized Photooxidation of Methionylglycine in Aqueous Solution. Spectral and Time Resolution of the Decaying (S .·. N)+ Radical Cation" J. Phys. Chem., 1996, 100(36), 14914-14921

Dirk M. Guldi, Jason Field, Jan Grodkowski, P. Neta, and Emanuel Vogel, "One-Electron Oxidation of Metalloporphycenes As Studied by Radiolytic Methods" J. Phys. Chem., 1996, 100(32), 13609-13614

G. L. Hug, B. Marciniak, K. Bobrowski, "Sensitized photooxidation of sulfur-containing amino acids and peptides in aqueous solution" J. Photochem. Photobiol. A., 1996, 95, 81.

J. Grodkowski, P. Neta, Y. Abdallah, P. Hambright,"Reduction and alkylation of rhodium porphyrin in alcohol solutions. Radiation chemical and photochemical studies" J. Phys. Chem., 1996, 100, 7066.

P. Neta, J. Grodkowski, A. B. Ross, "Rate constants for reactions of aliphatic carbon-centered radicals in aqueous solution" J. Phys. Chem. Ref. Data., 1996, 25, 709.

J. Grodkowski, P. Neta, P. Hambright, "Radiolytic reduction of rhodium porphyrins. Chain reaction in alkaline 2- propanol" J. Phys. Chem., 1995, 99, 6019.

B. Marciniak, G. L. Hug, J. Rozwadowski, K. Bobrowski, "The excited triplet state of N-(9-methylpurin-6-yl)pyridynium cation as an efficient photosensitizer in the oxidation of sulfur-containing amino acids. Laser flash and steady-state photolysis studies" J. Am. Chem. Soc., 1995, 117, 127.

B. Marciniak, G. L. Hug, K. Bobrowski, H. Kozubek, "On the mechanism of 4-carboxybenzophenone-sensitized photooxidation of methionine containing dipeptides and tripeptides" J. Phys. Chem., 1995, 99, 13560.

G. Burlinska, J. Michalik, K. Bobrowski, "An electron spin resonance study of gamma-irradiated polycrystalline methionine-containing peptides" Rad. Phys. Chem., 1994, 43, 425.

K. Bobrowski, G. L. Hug, B. Marciniak, H. Kozubek, "4-Carboxybenzophenone-sensitized photooxidation of sulfur-containing amino acids in alkaline aqueous solutions. Secondary photoreactions kinetics" J. Phys. Chem., 1994, 98, 537.

B. Marciniak, K. Bobrowski, G. L. Hug, J. Rozwadowski, "Photoinduced electron transfer between sulfur-containing carboxylic acids and 4-carboxybenzophenone triplet state in aqueous solutions" J. Phys. Chem., 1994, 98, 4854.

Ch. Schöneich, F. Zhao, K. P. Madden, K. Bobrowski, "Side chain fragmentation of N-terminal threonine or serine residue induced through intramolecular proton transfer to hydroxy sulfuranyl radical formed at neighboring methionine in dipeptides" J. Am. Chem. Soc., 1994, 116, 4641.

K. Bobrowski, G. L. Hug, B. Marciniak, "A reinvestigation of the mechanism of photoreduction of benzophenones by alkyl sulfides" J. Photochem. Photobiol. A., 1994, 81, 159.

Ch. Schöneich, K. Bobrowski, "Reaction of hydroxy sulfuranyl radical with molecular oxygen: electron transfer vs. addition" J. Phys. Chem., 1994, 98, 12613.